Sergey Girel

Sergey Girel

Chemist, M. Sc.

Analytical chemistry / Mass spectrometry

born 21.06.1986 in Novorossiysk, RUS

Current affiliation:

University of Geneva / PhD student

Section des science pharmaceutiques

Group of Prof. Dr. Serge Rudaz

sergey.girel@unige.ch

Research interests:

        High resolution mass spectrometry for complex workflows in metabolomics

        Hyphenation techniques for broad metabolite coverage

Chromatography: miniaturized and ballistic separations

        Data treatment and rational design of experiments (DoE), annotation methodology

        Applications of metabolomics in health and disease

   

Key skills: analytical development, LC/HRMS (FT, ICR, QToF), 1D/2D NMR, optical spectroscopy, metabolomics, complex structure elucidation, metabolite isolation and characterization, R

Experience: metabolomic pipeline development, metabolic profiling, determination, isolation and quantification of active principles, de novo structure elucidation of metabolites, identification of metabolic cross-kingdom interactions

Languages: Russian (Native), English (C1), German (C1) + Swiss dialect

Academic qualifications:

2019

University of Zürich, M. Sc. Chemistry – Analytical chemistry / Complex structure elucidation (Switzerland)

2018

University of Zürich, B. Sc. Chemistry and Business studies (Switzerland)

2010

Medical College of the City of Novorossiysk – Pharmacy (Russia)

Work experience:

2020

Federal competence center for agricultural research “Agroscope” (Switzerland) – LC/MS specialist

2019

Federal institute for sustainable agriculture (FiBL, Switzerland) – Research consultant

2018

University of Zürich (Switzerland) – Teaching assistant (Spectroscopy, BA level)


Comprehensive steroid profiling in patients with different stages of prostate cancer disease

Girel S., Markin P., Moskaleva N., Tobolkina E., Rudaz S., Appolonova S.

In preparation

Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid

Olesti E., Boccard J., Rahban R., Girel S., Moskaleva N. E., Zufferey F., Rossier M. F., Nef S., Rudaz S., González-Ruiz V.

Submitted

Investigation of several chromatographic approaches for untargeted profiling of central carbon metabolism

Girel. S, Guillarme D., Fekete S., Rudaz S., González-Ruiz V., Journal of Chromatography A, 463994 (2023)

(10.1016/j.chroma.2023.463994)

Teg58, a small regulatory RNA, is involved in regulating arginine biosynthesis and biofilm formation in St. aureus.

Manna, A.C., Leo, S., Girel, S. et al.  Sci Rep 12, 14963 (2022) (10.1038/s41598-022-18815-3)

Bioactive Nitrosylated and Nitrated N-(2-hydroxyphenyl) acetamides and Derived Oligomers: An Alternative Pathway to 2-Amidophenol-Derived Phytotoxic Metabolites.

Girel, S., Schütz, V., Bigler, L., Dörmann, P., Schulz, M. Molecules, 27, 4786 (2022) (10.3390/molecules27154786)

Separation and determination of cysteine enantiomers in plasma after derivatization with 4-fluoro-7-nitrobenzofurazan.

Ferré S., González-Ruiz V., Zangari J., Girel S., Martinou JC., Sardella R., Rudaz S. JPBA, 209, 114539 (2022) (10.1016/j.jpba.2021.114539)

Anti-microtubule activity of the traditional Chinese medicine herb Northern Ban Lan (Isatis tinctoria) leads to glucobrassicin.

Guan, P., Zhou, J., Girel, S., Zhu, X., Schwab, M., Zhang, K., Wang-Müller, Q., Bigler, L., and Nick, P.

J. Integr. Plant Biol., 63, 2058 (2021) (10.1111/jipb.13177)

Conversions of Benzoxazinoids and Downstream Metabolites by Soil Microorganisms.

Schütz V., Bigler L., Girel S., Laschke L., Sicker D., Schulz M. Front. Ecol. Evol., 7 (2019) (10.3389/fevo.2019.00238)